THE ROAD TO GOOD HEALTH
FROM A 58 YEAR OLD JANUARY 2009:
How do we know using this drug with other drugs many patients are using won't cause problems that could not be identified when the drug is used alone? I have high blood pressure so take the following one pill per day and my blood pressure is normal. But I worry about the side affects. I then got gout and arthritis in my knees. Took Allopurinal 300mg for 3 months and in the 4th month I seem to have swollen ankles and sometimes cannot walk. I realize this could be dropsey and the effects of meditcation. The pain was so bad I would take Voltarin 75ml & one Colchicine tablet thinking it was gout in my joints. Finally I decided from my Doctor Sally that it couls be the reaction of these drugs. I have now stopped after 4 months and trying to just take one tablet of brinerdine & more water intake daily--trying also to exercise more as my ankles get better. My diet is Ok and keep away from fatty foods, alcohol & food not good for my A Blood group. I believe in eating to your blood type. I used to wonder why after eating a nice roast meal or steak with gravy that I had to go to the toilet after??? I blamed the rstaurant yet all along it was my system. I am an A Blood type who cannot eat gravies, meats etc like an "O" blood type. Now I know and and a lot better..
Brinerdin tablets made by NOVERTIS for high blood pressure (reserpine, clopamide, dihydroergocristine, hydralazin) Antihypertensive agent. Dr. Sahelain comments: I am always cautious regarding introducing new drugs to my patients until several years have passed. It is not uncommon for side effects to be discovered after introduction of a drug. Read more on: http://www.raysahelian.com/novartis.html
(Oedema) or gout can be caused by high blood pressure and some blood pressure medicines. I have high blood pressure causeing the heart to work harder . Over the space of many years, this extra effort can lead to the heart muscle becoming thicker and less effective at pushing the blood round. This allows fluid to build up in your lower legs and ankles, which causes them to swell up. I take Colchicine 0.6mg every hour until the pain goes away although voltarin 75-100mg has worked to stop the pain.
Swollen ankles can also be a side effect of some blood pressure medicines, in particular calcium channel blockers. These medicines make your small blood vessels open wider and, in some people, this can cause more fluid to leak out of the blood vessels into the tissues. This fluid will collect around your ankles. Can lead to cellulitis (where the skin becomes infected and can lead to abscesses if not treated), varicose veins and venous ulcers (ulcers on the outer layers of the skin).Diuretic medicines increase the amount of fluid removed by your kidneys and this can help to get rid of any excess fluid from the body. This removes the build up of fluid from the tissues in your ankles.
My ankles get better when avoid foods with a lot of salt, especially Chinese food. Both heart problems and tight muscles are very common in people like me cutting off circulation and putting extra pressure on heart muscles are a cause and effect relationship. A Rheumatologist may prescribes methotrexate as well as Clinoril and Tramadol and this helps some. Prednisone (15 mgs/day) right away can take away the ankle swelling but watch side affects and only mainly use for women I think?
Diclofenac is a type of medicine that belongs to the group known as NSAIDs (non-steroidal anti-inflammatory drugs). NSAIDs relieve pain and reduce the inflammation and fever produced by the body's immune system. Diclofenac is considered safe, is faster acting than ibuprofen, and remains effective longer than paracetamol.
Dilcofenic is a relatively potent NSAID. It is a phenylacetic or benzeneacetic acid derivative with the chemically designation 2-(2,6-dichlorophenyl)amino phenylacetic acid or benzeneacetic acid, monosodium or monopotassium salt. Diclofenac sodium was first synthesised by Ciba-Geigy of Switzerland in 1965 and was launched as Voltaren in 1988.
Voltaren Emulgel contains diclofenac sodium, as diclofenac diethylammonium, and Cataflam contains diclofenac potassium as their respective active ingredients. In Cataflam, the potassium ion is used to replace the sodium ion but the active ingredient remains the same. The sodium salt and potassium salt used are biologically equivalent, with both being protonated by the acid in the stomach. One difference is that diclofenac potassium is slightly more soluble in water than diclofenac sodium.
Diclofenac has analgesic, antirheumatic, antipyretic and anti-inflammatory properties. It is a non-selective COX inhibitor. It works by blocking an enzyme in the body known as cyclo-oxygenase (COX). Cyclo-oxygenase is involved in the production of numerous chemicals in the body, including those known as prostaglandins. Prostaglandins are produced by the body in response to the presence of injury or disease and they make the nerves more sensitive to pain impulses. They produce pain, inflammation, and fever because they are hyperalgesic, pro-inflammatory, and pyretic. By reducing the amount of prostaglandin produced and inhibiting its biosynthesis by the body, diclofenac is able to relieve each of these symptoms.
The analgesic properties of diclofenac make it effective in cases of moderate to severe pain where rapidly relief is required. Diclofenac is used to treat a wide range of musculoskeletal disorders, including muscular aches, sprains, strains, tendonitis (tendon inflammation), bursitis, bruises, fractures and dislocations. It is effective in the treatment of joint disorders, including arthritis, osteoarthritis (a degenerative joint condition), rheumatoid arthritis (inflammation of the joints), ankylosing spondylitis (an inflammation of the vertebrae, also called Bechterew's disease), and pyrophosphate arthropathy (crystal deposits in the joints). Diclofenac in gel form is particularly useful for alleviating the pain and inflammation of muscle, joint, tendon and ligament injuries, and soft tissue rheumatism because it is applied topically to the skin.
Diclofenac is also used to provide relief for those who suffer from acute gout, lower back pain, migraine headache, menstrual pain and dysmenorrhoea. It can alleviate the discomfort associated with inflammatory infections of the ear, nose, or throat, post-operative pain or inflammation due to trauma following dental, orthopaedic, or other minor surgery.
The absorption process begins immediately after the tablets are taken, with pain relief usually occurring within 15 to 30 minutes. With Cataflam oral tablets, the diclofenac potassium is quickly released into the blood stream to provide fast relief from pain. Approximately half of the diclofenac is metabolised during its first passage through the liver. About 60% of the administered dose will be excreted through the urine, via the kidneys, with less than 1% of that which is excreted remaining unchanged. The rest of the dose will be eliminated as metabolites through bile and in the faeces. The pharmacokinetic behaviour of diclofenac will not change after repeated doses and diclofenac will not accumulate in the body provided that the dosages are taken at regular intervals.
The biotransformation of diclofenac occurs partly because of the glucuronidation of the intact molecule, but it is mostly the result of single and multiple hydroxylation and methoxylation. This creates several phenolic metabolites, most of which are converted to glucuronide conjugates.
Diclofenac enters the synovial fluid, where the maximum concentrations will be measured 2 to 4 hours after peak plasma levels are reached. Two hours after reaching peak plasma levels, the concentration of diclofenac will be higher in the synovial fluid than in the plasma. The terminal half-life for diclfenac in plasma is 1 to 2 hours, while the half-life for the elimination from the synovial fluid is 3 to 6 hours. http://www.assistpainrelief.com/info/diclofenac/
DO YOURSELF AND BODY A FAVOUR:
HERE HOW TO AVOID HEART ATACKS:
To prevent heart attack it is important to eat the foods and have the drinks according to your Blood group. Eating the wrobng foods just increases heart attacks so check below on your blood groups and stick to this diet of foods. I found that whenever I ate roast meals with gravies or steaks with gravies I had to go to the toilet. I blamed the restaurant for the food but all along it was my body so once I changed my eating habits and I love vegetables (with small amounts of meats) I never had this problem. It works!
Read about Serious potential Yasmin side effects
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